Professor Paul Shiels

Professor of Cellular Gerontology at the Wolfson Wohl Translational Research Center at the University of Glasgow

Online Profile

Project Specialisms

Geroscience, the Human Exposome

  • Chair of the Scientific Advisory Board British Soc. Research on Ageing (2023-)

  • Chair of the Flanders Fonds Wetenschappelijk Onderzoek - Vlaanderen, Med 6 Fellowship Funding Panel (2022-)

  • Panel member for the UK Research Partnership Investment Fund (UKRPIF) (2023-)

Research Experience

Paul is Professor of Cellular Gerontology at the Wolfson Wohl Translational Research Center at the University of Glasgow. He is a founder member of GARNER, the Glasgow Ageing Research Network. Paul has established a reputation in the biology of ageing with over 170 peer-reviewed publications in this arena.Prof. Shiels has acted as an expert on the Biology of Ageing in a number of national policy advising consortia, including pSoBiD for the Chief Medical Officer of Scotland. His research has involved determining socio-economic, psychological, lifestyle and biological factors that are required for healthy ageing. He was the first to report on socioeconomic status and nutritional factors affecting epigenetic influences on health.His current research portfolio comprises investigation and application of novel senotherapies and how the microbiome impacts on age related health.Prof. Shiels has a proven track record in public dissemination of his research including the provision of expert commentary for the BBC and ABC TV networks and as a Panellist at the Edinburgh International Science Festival and the Edinburgh International Book Festival.

Publications

KoLing Chan, CKM Lo, Xiao-Yan Chen, Patrick Ip, MPH Wing Cheong Leung, Paul G Shiels, Jill P Pell, Helen Minnis, FK Ho. Association between intimate partner violence and leukocyte telomere length: a retrospective cohort study of 144,049UK Biobank participants. Epidemiology and Psychiatric Science in press. IF6.892
Beatriz Baptista,Susane Fanton,Marcia Ribiero,Ludmila F.M.F. Cardozo,Bruna Regis,LiviaAlvarenga,Marcelo Ribeiro-Alves,Nathaiia Ursoli Baptista,Nathaly Alcazar NAmorim,Andresa Aparecida Berretta, Paul G Shiels and Denise Mafra.The effect of Brazilian Green Propolis extract on inflammation in patients with chronic kidney disease on peritoneal dialysis: a randomized double-blind controlled clinical trial Phytomed. PHYMED-D-22-02101R2 in press
Ziyi Zhou, Camilla K M Lo, Ko Ling Chan, Rachel S Y Chung, Jill P Pell, Helen Minnis, Paul G Shiels, Patrick Ip, Frederick K Ho. Child maltreatment and telomere length in middle and older age: A retrospective cohort study of141,748 participants in UK Biobank BJPsych-22-0673.R2 in press IF 9.319
Claire Hill, Seamus Duffy Laura M. Kettyle, Liane McGlynn , Nina Sandholm, RanyM. Salem, Alex Thompson, Elizabeth J. Swan, Jill Kilner, Peter Rossing , GENIE consortium, Paul G. Shiels, Maria Lajer, Per-Henrik Groop, Alexander Peter Maxwell and Amy Jayne McKnight Differential methylation of telomere-related genes is associated with kidney disease in individuals with type 1 diabetes Genes (2023) 14(5):1029
Paul G Shiels, Ngoc Tran, Jen McCavitt, Ognian Neytchev and Peter Stenvinkel .Chronic kidney disease and the exposome of ageing.  Sub Cell Biochem.2023. 103: 79-94 6. Hobson S, Arefin S, Witasp A,, Hernandez L,Kublickiene K, Shiels PG, Stenvinkel P Chronic kidney diseases - a unique clinical model of accelerated vascular ageing can benefit from novel anti-aging therapeutic options Circulation Research in press
Laís de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, Drielly C. M. deVargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila F. M.F. Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra Cinnamon: an aromatic condiment applicable to chronic kidney disease Kidney Res Clin Pract2023;42(1):4-26
Stenvinkel P Shiels PG and Johnson RJ Lessons from evolution by natural selection: an unprecedented opportunity to use biomimetics to improve planetary health J Environ Manage. 2022;328:116981. IF 8.626 9. Kemp JA, Alvarenga L, Cardozo LFMF, Dai L, Stenvinkel P, Shiels PG, Hackeng TM, Schurgers LJ, Mafra D Dysbiosis in Patients with Chronic Kidney Disease: Let Us Talk About Vitamin K.Curr Nutr Rep. 2022. doi: 10.1007/s13668-
Mafra D, Ribeiro M, Fonseca L, Regis B, Cardozo LFMF, Fragoso Dos Santos H, Emiliano de Jesus H, Schultz J, Shiels PG, Stenvinkel P, Rosado A Archaea from the gut microbiota of humans: Could be linked to chronic diseases? Anaerobe.2022 102629. doi: 10.1016/j.anaerobe.2022.102629.
Mafra D, Ugochukwu SA, Borges NA, Cardozo LFMF, Stenvinkel P, Shiels PG . Food for healthier aging: power on your plate.Crit Rev Food Sci Nutr. 2022 12:1- IF11.17
Marcia Ribeiro, Livia Alvarenga, Ludmila Cardozo, Julie A. Kemp Ligia S. Lima, JonatasS. de Almeida, Viviane de O. Leal, Peter Stenvinkel, Paul G. Shiels, Denise Mafra. The magical smell and taste: Can coffee be good to patients with cardiometabolic disease? Crit Rev Food Sci Nutr. 2022 :1-22. IF 11.17
Laís de Souza Gouveia Moreira, Isabela de Souza da Costa Brum, DriellyCristhiny Mendes de Vargas Reis, Liana Trugilho, Tuany R. Chermut, Marta Esgalhado, Ludmila FMF Cardozo, Peter Stenvinkel, Paul G. Shiels, Denise Mafra.Cinnamon – an aromatic condiment suitable for chronic kidney disease Kidney Res Clin Pract. 2023;42(1):4-2
Mafra D, Cardozo L, Ribeiro-Alves M, Bergman P, Shiels PG, Stenvinkel P. Choline plasma levels are related to mRNA Nrf2 expression in chronic kidney disease?Clin Nutr ESPEN. 2022 50:318-321. IF 7.634
Thomas Ebert, Ngoc Tran, Leon Schurgers, Peter Stenvinkel, Paul G. Shiels Aging– Oxidative stress, PTMs and disease. Mol Aspects Med. 2022 8;86:101099.